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Lennart Philipson Dies

Lennart Philipson, a virologist and microbiologist, died in June. In this week's PLoS Biology, David Baltimore writes that Philipson was "a force of nature" in the lab. "He is particularly noted for his work on the cellular receptors for viruses, on the assembly of adenoviruses, and on the control of adenovirus gene expression, but he made contributions to fields as disparate as serology and structure determination and everything in between," Balitmore says. He adds that Philipson also helped lead scientific institutes like the Wallenberg Laboratory in Sweden and the European Molecular Biology Laboratory. "Lennart was a rare and irreplaceable person, a true individual. His science was path-finding, his leadership strong and imaginative, his friendship deep. He will be missed by all who knew him," Baltimore says.

The Scan

Study Points to Tuberculosis Protection by Gaucher Disease Mutation

A mutation linked to Gaucher disease in the Ashkenazi Jewish population appears to boost Mycobacterium tuberculosis resistance in a zebrafish model of the lysosomal storage condition, a new PNAS study finds.

SpliceVault Portal Provides Look at RNA Splicing Changes Linked to Genetic Variants

The portal, described in Nature Genetics, houses variant-related messenger RNA splicing insights drawn from RNA sequencing data in nearly 335,700 samples — a set known as the 300K-RNA resource.

Automated Sequencing Pipeline Appears to Allow Rapid SARS-CoV-2 Lineage Detection in Nevada Study

Researchers in the Journal of Molecular Diagnostics describe and assess a Clear Labs Dx automated workflow, sequencing, and bioinformatic analysis method for quickly identifying SARS-CoV-2 lineages.

UK Team Presents Genetic, Epigenetic Sequencing Method

Using enzymatic DNA preparation steps, researchers in Nature Biotechnology develop a strategy for sequencing DNA, along with 5-methylcytosine and 5-hydroxymethylcytosine, on existing sequencers.