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Lee Hood Promotes P4 at AACC

During the final plenary session at the 2010 annual meeting of the American Association for Clinical Chemistry, Leroy Hood spoke of "transforming healthcare" via the P4 "revolution," encompassing a predictive, personalized, preventive, and participatory approach to health and disease — a "paradigm shift" that he says will produce "enormous economic opportunities" with "dramatically lower[ed] health care costs." Hood discussed the commitment at Institute for Systems Biology and other institutions – notably the Ohio State University College of Medicine, co-founder of the P4 Medicine Institute, along with the ISB – to next-generation genomic, proteomic, transcriptomic, and microfluidic technologies, as well as integrative computational methods.

Blood-based diagnostics, he told meeting attendees, "will be the key to P4 medicine." Hood envisions that in the next 10 years, physicians will adopt a "systems approach to disease," whole-genome sequencing will be performed in the familial context, and patient-specific assays will be used biannually and will interrogate 2,500 proteins in order to quantify "wellness."

Hood also spoke of his intent to establish, in Seattle, "a very large facility to be able to accumulate human genome sequences as they become available, with phenotypes and adequate records," so that investigators can mine the data for "the collective mining that will create the predictive medicine of the future.

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