During the final plenary session at the 2010 annual meeting of the American Association for Clinical Chemistry, Leroy Hood spoke of "transforming healthcare" via the P4 "revolution," encompassing a predictive, personalized, preventive, and participatory approach to health and disease — a "paradigm shift" that he says will produce "enormous economic opportunities" with "dramatically lower[ed] health care costs." Hood discussed the commitment at Institute for Systems Biology and other institutions – notably the Ohio State University College of Medicine,