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Lee Hood on Nanomedicine

Leroy Hood has co-penned an article in this month's issue of Scientific American, along with James Heath and Mark Davis, and it delves into using a systems approach to model complex diseases like cancer. Extensive work goes into creating computational models that can predict disease progression in say, prostate cancer, but knowing the molecular pathways involved can help with early detection and stratification. The article also covers nanoscale therapies, like RNAi, and looks ahead. "Once the principles of nanoparticle function in humans are more fully established, the concept can be applied to create a therapeutic system that can carry combinations of drugs, each with its own customized release rates," they write.

The Scan

Tens of Millions Saved

The Associated Press writes that vaccines against COVID-19 saved an estimated 20 million lives in their first year.

Supersized Bacterium

NPR reports that researchers have found and characterized a bacterium that is visible to the naked eye.

Also Subvariants

Moderna says its bivalent SARS-CoV-2 vaccine leads to a strong immune response against Omicron subvariants, the Wall Street Journal reports.

Science Papers Present Gene-Edited Mouse Models of Liver Cancer, Hürthle Cell Carcinoma Analysis

In Science this week: a collection of mouse models of primary liver cancer, and more.