Leroy Hood has co-penned an article in this month's issue of Scientific American, along with James Heath and Mark Davis, and it delves into using a systems approach to model complex diseases like cancer. Extensive work goes into creating computational models that can predict disease progression in say, prostate cancer, but knowing the molecular pathways involved can help with early detection and stratification. The article also covers nanoscale therapies, like RNAi, and looks ahead.

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Germany's Project DEAL has come to an agreement with the publisher Wiley over journal access and open-access publishing, ScienceInsider reports.

Researchers uncover additional loci associated with lifespan, which the Telegraph says could be folded into a genetic test.

A Canadian panel recommends public coverage of the gene therapy Kymriah if its cost comes down, the Globe and Mail reports.

In Nucleic Acids Research this week: new accurate quantification by sequencing approach, CNV breakpoints in Plasmodium falciparum, and more.