Leroy Hood has co-penned an article in this month's issue of Scientific American, along with James Heath and Mark Davis, and it delves into using a systems approach to model complex diseases like cancer. Extensive work goes into creating computational models that can predict disease progression in say, prostate cancer, but knowing the molecular pathways involved can help with early detection and stratification. The article also covers nanoscale therapies, like RNAi, and looks ahead.

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In Science this week: International Wheat Genome Sequencing Consortium publishes the bread wheat cultivar Chinese Spring reference genome, and more.

At his FDA Law Blog, Jeffrey Gibbs discusses FDA's technical assistance for the draft Diagnostic Accuracy and Innovation Act.

The New York Times reports that genetic testing has uncovered unfaithful penguins at a Utah aquarium.

Cancer researcher loses funding under new Wellcome Trust anti-bullying policies, the Guardian reports.