Leroy Hood has co-penned an article in this month's issue of Scientific American, along with James Heath and Mark Davis, and it delves into using a systems approach to model complex diseases like cancer. Extensive work goes into creating computational models that can predict disease progression in say, prostate cancer, but knowing the molecular pathways involved can help with early detection and stratification. The article also covers nanoscale therapies, like RNAi, and looks ahead.

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Robert Redfield is floated as the next director of the US Centers for Disease Control and Prevention, the Washington Post reports.

The New York Times writes that the National Institutes of Health's All of Us Research Program is "ambitious" and that some are concerned it might be overly so.

Representative Lamar Smith's criticism of the National Science Foundation has "changed the nature of the conversation," according to ScienceInsider.

In PLOS this week: non-coding RNA function in yeast, transcriptomic profiles of malaria parasites, and more.