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A synthetic base pair is replicated similarly to how natural base pairs are, report the Universität Konstanz's Karin Betz and her colleagues in Nature Chemical Biology. The researchers obtained and analyzed X-ray crystal structures of Taq DNA polymerase I bound to templates with either a natural base pair or the unnatural base pair dNaM-d5SICS at different stages of replication. From this, they found that dNaM-d5SICS is efficiently replicated.

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The UK has given emergency authorization for Pfizer and BioNTech's SARS-CoV-2 vaccine, the Associated Press reports.

A US advisory committee says healthcare workers and nursing home residents should be prioritized to receive a SARS-CoV-2 vaccine, according to the Financial Times.

The Wall Street Journal reports North Korean hackers have targeted half a dozen companies developing SARS-CoV-2 vaccines.

In Cell this week: long-term SARS-CoV-2 shedding, examination of the effects of a coronavirus spike protein mutation, and more.