A synthetic base pair is replicated similarly to how natural base pairs are, report the Universität Konstanz's Karin Betz and her colleagues in Nature Chemical Biology. The researchers obtained and analyzed X-ray crystal structures of Taq DNA polymerase I bound to templates with either a natural base pair or the unnatural base pair dNaM-d5SICS at different stages of replication. From this, they found that dNaM-d5SICS is efficiently replicated.

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