Skip to main content
Premium Trial:

Request an Annual Quote

But, But, It's a Cool Project...

The study of model organisms "can elucidate important processes relevant to human health and disease," writes Jeremy Berg at the NIGMS Feedback Loop blog, as a recap of his talk from the Genetics Society of America meeting. (At the time, the Daily Scan covered his talk here.) He adds that "some applicants who use model organisms try to explain the significance of their project by making relatively tenuous links to specific clinical areas. As an alternative, they should consider highlighting the study’s importance to a basic field of biomedical or behavioral research and the reason for using a specific experimental system." This is particularly important as, from an analysis of NIGMS R01 applications, Berg finds "that approach and significance are the most important factors, on average, in determining the overall impact score."

"Makes you salivate for similar analyses from all the other ICs doesn't it?" adds DrugMonkey at his post on the findings.

The Scan

Study Finds Sorghum Genetic Loci Influencing Composition, Function of Human Gut Microbes

Focusing on microbes found in the human gut microbiome, researchers in Nature Communications identified 10 sorghum loci that appear to influence the microbial taxa or microbial metabolite features.

Treatment Costs May Not Coincide With R&D Investment, Study Suggests

Researchers in JAMA Network Open did not find an association between ultimate treatment costs and investments in a drug when they analyzed available data on 60 approved drugs.

Sleep-Related Variants Show Low Penetrance in Large Population Analysis

A limited number of variants had documented sleep effects in an investigation in PLOS Genetics of 10 genes with reported sleep ties in nearly 192,000 participants in four population studies.

Researchers Develop Polygenic Risk Scores for Dozens of Disease-Related Exposures

With genetic data from two large population cohorts and summary statistics from prior genome-wide association studies, researchers came up with 27 exposure polygenic risk scores in the American Journal of Human Genetics.