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But, But, It's a Cool Project...

The study of model organisms "can elucidate important processes relevant to human health and disease," writes Jeremy Berg at the NIGMS Feedback Loop blog, as a recap of his talk from the Genetics Society of America meeting. (At the time, the Daily Scan covered his talk here.) He adds that "some applicants who use model organisms try to explain the significance of their project by making relatively tenuous links to specific clinical areas. As an alternative, they should consider highlighting the study’s importance to a basic field of biomedical or behavioral research and the reason for using a specific experimental system." This is particularly important as, from an analysis of NIGMS R01 applications, Berg finds "that approach and significance are the most important factors, on average, in determining the overall impact score."

"Makes you salivate for similar analyses from all the other ICs doesn't it?" adds DrugMonkey at his post on the findings.

The Scan

For Better Odds

Bloomberg reports that a child has been born following polygenic risk score screening as an embryo.

Booster Decision Expected

The New York Times reports the US Food and Drug Administration is expected to authorize a booster dose of the Pfizer-BioNTech SARS-CoV-2 vaccine this week for individuals over 65 or at high risk.

Snipping HIV Out

The Philadelphia Inquirer reports Temple University researchers are to test a gene-editing approach for treating HIV.

PLOS Papers on Cancer Risk Scores, Typhoid Fever in Colombia, Streptococcus Protection

In PLOS this week: application of cancer polygenic risk scores across ancestries, genetic diversity of typhoid fever-causing Salmonella, and more.