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It Just Kinda Does

"Given the huge numbers of possible compounds, and the relatively tiny fraction of those we can screen, why does high-throughput screening even work at all?" asks Derek Lowe at In the Pipeline. A recent paper from the Shoichet group at UCSF compared the contents of different screening libraries to what natural products generally look like, finding that the libraries appear to lean toward having compounds with structures similar to natural products, which, Lowe says, "we can reasonably assume have generally evolved to have some sort of biological activity."

The Scan

Pig Organ Transplants Considered

The Wall Street Journal reports that the US Food and Drug Administration may soon allow clinical trials that involve transplanting pig organs into humans.

'Poo-Bank' Proposal

Harvard Medical School researchers suggest people should bank stool samples when they are young to transplant when they later develop age-related diseases.

Spurred to Develop Again

New Scientist reports that researchers may have uncovered why about 60 percent of in vitro fertilization embryos stop developing.

Science Papers Examine Breast Milk Cell Populations, Cerebral Cortex Cellular Diversity, Micronesia Population History

In Science this week: unique cell populations found within breast milk, 100 transcriptionally distinct cell populations uncovered in the cerebral cortex, and more.