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Irony at the NIH

Mike the Mad Biologist is a bit taken aback as he points to a statistical analysis in PLoS One that shows the NIH peer review process is not exactly steeped in the principles of statistical sampling. The paper says that the current number of recommended reviewers for each grant doesn't provide the level of precision that the NIH mandates for scoring the application. The study authors write, "It is commonly accepted that NIH will not fund clinical trials that do not include a cogent sample size determination. It is ironic that NIH insists on this analysis for clinical studies but has not recognized its value in evaluating its own system of peer review."

The Scan

Genetic Tests Lead to Potential Prognostic Variants in Dutch Children With Dilated Cardiomyopathy

Researchers in Circulation: Genomic and Precision Medicine found that the presence of pathogenic or likely pathogenic variants was linked to increased risk of death and poorer outcomes in children with pediatric dilated cardiomyopathy.

Fragile X Syndrome Mutations Found With Comprehensive Testing Method

Researchers in Clinical Chemistry found fragile X syndrome expansions and other FMR1 mutations with ties to the intellectual disability condition using a long-range PCR and long-read sequencing approach.

Team Presents Strategy for Speedy Species Detection in Metagenomic Sequence Data

A computational approach presented in PLOS Computational Biology produced fewer false-positive species identifications in simulated and authentic metagenomic sequences.

Genetic Risk Factors for Hypertension Can Help Identify Those at Risk for Cardiovascular Disease

Genetically predicted high blood pressure risk is also associated with increased cardiovascular disease risk, a new JAMA Cardiology study says.