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In the Interpretation

Stanford University's Konrad Karczewski and colleagues have developed an online tool to analyze personal genomic data, writes Daniel MacArthur at Genomes Unzipped. As MacArthur notes, the tool, called the Interpretome, currently works with 23andMe and Lumigenix data. "This is an awesome idea. Basically, you analyze your 23andMe raw data with a variety of tools, without actually having to send it anywhere," writes Davidski at the European Genetics and Anthropology Blog.

At his own blog, Karczewski writes that he and the other teaching assistants for Stanford's Personalized Medicine and Genomics course developed the browser-based tool to help the students interpret their data. "The site provides an open-source framework for personal genome interpretation, demonstrating the power of genotyping for ancestral and clinical analysis," Karczewski says, adding that the tool is not to be used for diagnostic purposes.

At Genomes Unzipped, MacArthur says that he suspects that the tool's Principal Component Analysis package will be popular as it helps "you to place your genetic data in the context of worldwide patterns of genetic variation," he says. An indeed, the European Genetics and Anthropology Blog's Davidski has also test the PCA tool out. Meanwhile, The Genetic Genealogist is intrigued by the advanced settings tab, where tweaks can be made to the analysis settings, and that the site allows for imputation.

The Scan

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.