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The Interest of the Naked Mole Rat

The University of Liverpool's Joao Pedro Magalhaes and his colleagues announced that they have sequenced the naked mole rat genome, reports the Short Sharp Science blog at New Scientist. The blog notes that naked mole rats have a social structure similar to that of leafcutter ants and that they live a long time and appear to be resistant to cancer. With this draft sequence, researchers can begin to study why that is so. "You can start to look, for example, at the DNA repair systems in naked mole rats, and find out if they are different from mice, which have a much shorter lifespan," Magalhaes tells BBC Nature. "It's a first step to uncovering the mysteries of this creature's remarkable longevity and its resistance to diseases."

The Scan

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.