MassGenomics' Dan Koboldt heard a talk by Daniel Zerbino on de Bruijn graphs and Velvet’s assembly programs -- Koboldt adds that despite the dense topic, the room was packed. From the talk, Koboldt says, "I almost understand [de Bruijn graphs]" and he also summarizes the four steps of Velvet assembly: building the de Bruijin graph, simplifying the graph, removing tips, and removing bubbles.