At his Personal Genome blog, Jason Bobe has a post on what it's going to take to make people willing to get their genome sequenced and then share the data. His "roadmap to willingness" has three parts: to succeed, he writes, "personal genomics needs to be cheap (feasible), useful (desirable), and safe (viable)." Where all three of those components can be found together, he says, there's a good chance for personal genomics to take off.