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If It Makes You Feel Any Better, the Chairs Are Really Uncomfortable

The ASHG meeting is in full swing with sunburned scientists showing up to give their talks and everyone getting adjusted to local time here in Hawaii. (Yep, Daily Scan's on the scene.) This week, attendees got caught up on what the 1,000 Genomes project is up to — the University of Oxford's Gil McVean said to keep an eye out for data from the initiative's pilot studies in November or December. Also, Elaine Mardis discussed work on cancer genome sequencing, particularly a breast cancer quartet study, and Pardis Sabeti focused on how to search the genome for signals of natural selection, among others.

Later, ASHG president Ed McCabe spoke about the interesting hypothesis that perhaps dogs domesticated humans. Really, he says that it was more similar to co-evolution, but it's fun to think about Rover instilling in us a need to throw tennis balls around the yard.

Cancer genomics took center stage yesterday as Gaddy Getz discussed the role of next-generation sequencing in understanding cancer, replacing arrays and capillary sequencing. Then, UCLA's Stan Nelson went over his universal aligner tool, BFast.

Oxford's Peter Donnelly cited his recent work with the Wellcome Case Control Consortium when he discussed the need to be vigilant in analyzing copy number variation data – an interesting CNV on chromosome 5 on the reference genome turned out to really be on the X chromosome, accounting for the effect they saw in female study participants. In another session, Steve Scherer went over the CNVs implicated in autism spectrum disorders.

For more ASHG updates, check out Luke Jostins' posts rounding up talks from the second day as well as his chats with next-gen sequencing companies.

The Scan

Not Yet a Permanent One

NPR says the lack of a permanent Food and Drug Administration commissioner has "flummoxed" public health officials.

Unfair Targeting

Technology Review writes that a new report says the US has been unfairly targeting Chinese and Chinese-American individuals in economic espionage cases.

Limited Rapid Testing

The New York Times wonders why rapid tests for COVID-19 are not widely available in the US.

Genome Research Papers on IPAFinder, Structural Variant Expression Effects, Single-Cell RNA-Seq Markers

In Genome Research this week: IPAFinder method to detect intronic polyadenylation, influence of structural variants on gene expression, and more.