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I'd Rather Be a Rodent

A story from the New York Times covers a report from the Department of Health and Human Services saying that the US Food and Drug Administration "does very little to ensure the safety of the millions of people who participate in clinical trials," according to the article. Apparently, in more than two-thirds of cases where clinical trials inspectors determined that there were serious problems, FDA officials "downgraded" the reports in ways that made those problems appear less important. The article quotes U Penn's Arthur Caplan as saying, "In many ways, rats and mice get greater protection as research subjects in the United States than do humans."


The Scan

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.

Study Reveals Potential Sex-Specific Role for Noncoding RNA in Depression

A long, noncoding RNA called FEDORA appears to be a sex-specific regulator of major depressive disorder, affecting more women, researchers report in Science Advances.

New mRNA Vaccines Offer Hope for Fighting Malaria

A George Washington University-led team has developed mRNA vaccines for malaria that appear to provide protection in mice, as they report in NPJ Vaccines.

Unique Germline Variants Found Among Black Prostate Cancer Patients

Through an exome sequencing study appearing in JCO Precision Oncology, researchers have found unique pathogenic or likely pathogenic variants within a cohort of Black prostate cancer patients.