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The Human Genome Bubble

It's not just financial systems that experience bubbles, reports the arXiv blog. Another recent bubble was the Human Genome Project, say Monika Gisler and her colleagues at the Swiss Federal Institute of Technology. They say that the project generated high expectations — to revolutionize medicine and change society — which got the US government to invest in the effort. That investment led to private-public competition which, they say, helped support the bubble and diminish concerns about the project's uncertainties. Most of those fears, the authors add, have come to pass, though the effort was a boon to technology development. The authors also conclude that bubbles, if managed properly, can be good. "Governments can take advantage of the social bubble mechanism to catalyze long-term investments by the private sector, which would not otherwise be supported," they say.

The Scan

Ancient Greek Army Ancestry Highlights Mercenary Role in Historical Migrations

By profiling genomic patterns in 5th century samples from in and around Himera, researchers saw diverse ancestry in Greek army representatives in the region, as they report in PNAS.

Estonian Biobank Team Digs into Results Return Strategies, Experiences

Researchers in the European Journal of Human Genetics outline a procedure developed for individual return of results for the population biobank, along with participant experiences conveyed in survey data.

Rare Recessive Disease Insights Found in Individual Genomes

Researchers predict in Genome Medicine cross-population deletions and autosomal recessive disease impacts by analyzing recurrent nonallelic homologous recombination-related deletions.

Genetic Tests Lead to Potential Prognostic Variants in Dutch Children With Dilated Cardiomyopathy

Researchers in Circulation: Genomic and Precision Medicine found that the presence of pathogenic or likely pathogenic variants was linked to increased risk of death and poorer outcomes in children with pediatric dilated cardiomyopathy.