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HSF2 Aids Fertility in Mice

A study out of the Turku Centre for Biotechnology in Finland used ChIP-chip analysis to discover that heat shock factor 2 (HSF2), a transcription factor involved in spermatogenesis, binds the male-specific region of the mouse Y chromosome long arm (MSYq) in mouse testis. Deletions in this gene are known to result in sperm head defects and impaired fertility. In their study published yesterday in PNAS, they found that disruption of the Hsf2 gene resulted in similar phenotypic changes as deletions in MSYq, suggesting that HSF2 plays a serious role in regulating MSYq genes and the quality of sperm.

The Scan

mRNA-Based Vaccine on the Way in China

China may soon have its own mRNA-based vaccine, according to Nature News.

Arranged Killing, Fraud Alleged by Prosecutors

The Wall Street Journal reports that prosecutors allege that the co-founder of a biotech arranged to have a business associate who threatened to expose him as a fraud killed.

Whirlwind Decade of CRISPR

The New York Times looks back at the 10 years since the University of California, Berkeley's Jennifer Doudna and her colleagues published their CRISPR paper.

PNAS Papers on Blue Cone Monochromacy Structural Variants, HIV-1 Mutant, T-ALL

In PNAS this week: structural variants linked to blue cone monochromacy, HIV-1 variants affecting the matrix protein p17, and more.