University of Ulm scientists have identified biomarkers that are indicative of telomere shortening. CRAMP, stathmin, EF-1α, and chitinase are proteins that they found to be secreted from telomere-dysfunctional bone-marrow cells of late generation telomerase knockout mice. Their study, which was published this week in PNAS, showed an increase in expression of these markers in the blood of aging and geriatric people with age-related disease; it also allowed them to discriminate between young and old and between disease and healthy control groups.
How to Tell If You're Old (or Getting There)
Aug 13, 2008