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How to Make a Sequencing Splash

Bloggers are having a field day with Illumina's announcement that it will launch a new next-gen sequencing platform called HiSeq 2000 that can produce as much as 200 gigabases of sequence data per run.

Daniel MacArthur at Genetic Future blogs that "Illumina's announcement will almost certainly help to cement its position as the technology provider of choice for genome facilities," adding a note to readers that "this new machine, while impressive, represents an incremental advance rather than a dramatic technological leap forward."

At PolITiGenomics, David Dooling adds, "The ability to sequence a tumor and normal genome from an individual in a single instrument run in about a week is really going to change the calculation (and economics) for cancer sequencing going forward."

And Keith Robison at Omics! Omics! writes, "The one devil in trying to do lots of profiles is that means making that many libraries, which is the step that everyone still groans about (particularly my vendors!)." He adds his prediction that "once the library throughput question is solved it would seem that arrays are going to be in big trouble."