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How to Make a Sequencing Splash

Bloggers are having a field day with Illumina's announcement that it will launch a new next-gen sequencing platform called HiSeq 2000 that can produce as much as 200 gigabases of sequence data per run.

Daniel MacArthur at Genetic Future blogs that "Illumina's announcement will almost certainly help to cement its position as the technology provider of choice for genome facilities," adding a note to readers that "this new machine, while impressive, represents an incremental advance rather than a dramatic technological leap forward."

At PolITiGenomics, David Dooling adds, "The ability to sequence a tumor and normal genome from an individual in a single instrument run in about a week is really going to change the calculation (and economics) for cancer sequencing going forward."

And Keith Robison at Omics! Omics! writes, "The one devil in trying to do lots of profiles is that means making that many libraries, which is the step that everyone still groans about (particularly my vendors!)." He adds his prediction that "once the library throughput question is solved it would seem that arrays are going to be in big trouble."

The Scan

Genetic Risk Factors for Hypertension Can Help Identify Those at Risk for Cardiovascular Disease

Genetically predicted high blood pressure risk is also associated with increased cardiovascular disease risk, a new JAMA Cardiology study says.

Circulating Tumor DNA Linked to Post-Treatment Relapse in Breast Cancer

Post-treatment detection of circulating tumor DNA may identify breast cancer patients who are more likely to relapse, a new JCO Precision Oncology study finds.

Genetics Influence Level of Depression Tied to Trauma Exposure, Study Finds

Researchers examine the interplay of trauma, genetics, and major depressive disorder in JAMA Psychiatry.

UCLA Team Reports Cost-Effective Liquid Biopsy Approach for Cancer Detection

The researchers report in Nature Communications that their liquid biopsy approach has high specificity in detecting all- and early-stage cancers.