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How Low Can You Go?

The Scientist spoke with five researchers who are bring their studies down to the single-cell level. Joris Vermeesch at the Center for Human Genetics in Belgium is working on looking at the entire genomes of the eight cells that make up a blastomere to improve in vitro fertilization. UCSF's Jonathan Weissman is determining protein abundance in single cells — his team found that though housekeeping genes are stable, proteins vary. Other researchers they include are Ramunas Stepanauskas at the Bigelow Laboratory for Ocean Sciences, Xiaoliang Sunney Xie at Harvard, and Renato Zenobi at ETH.

The Scan

Tens of Millions Saved

The Associated Press writes that vaccines against COVID-19 saved an estimated 20 million lives in their first year.

Supersized Bacterium

NPR reports that researchers have found and characterized a bacterium that is visible to the naked eye.

Also Subvariants

Moderna says its bivalent SARS-CoV-2 vaccine leads to a strong immune response against Omicron subvariants, the Wall Street Journal reports.

Science Papers Present Gene-Edited Mouse Models of Liver Cancer, Hürthle Cell Carcinoma Analysis

In Science this week: a collection of mouse models of primary liver cancer, and more.