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To the Hotspots

Pharmaceutical companies are investing in shifting their operations to a few bioscience hotspots, even at a time of cutbacks, says this Wall Street Journal article. While cities like Boston and San Francisco are being helped by companies' relocations and the construction it entails, the suburban areas being left like New Jersey and Connecticut are not doing as well. "Companies are able to offset the high costs of operating in established clusters with the increased odds of innovation due to deep, rich talent pools and infrastructure," says a report from real-estate advisory firm Jones Lang LaSalle.

"The micro environment really matters," adds Pfizer's Rod MacKenzie. "It really is helpful if you are right next door to scientists and other institutions."

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.