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Hey, Phred, Thanks for the Inaccuracies

Following up on her post last week asking about the accuracy of basecallers, Sandra Porter writes that she succeeded in her quest to find someone who had done a thorough study of chromatogram data processed with phred. Applied Biosystems and collaborators at Wash U and Baylor did work on this a few years ago in a review of 20,000 chromatograms. The upshot, in a quote from ABI's results: "Since phred replaces (and ignores) the initial called sequence, re-processing KB-analyzed samples with phred will, on average, degrade the accuracy of the analysis in terms of actual sequence error," according to the post.

 

The Scan

mRNA-Based Vaccine on the Way in China

China may soon have its own mRNA-based vaccine, according to Nature News.

Arranged Killing, Fraud Alleged by Prosecutors

The Wall Street Journal reports that prosecutors allege that the co-founder of a biotech arranged to have a business associate who threatened to expose him as a fraud killed.

Whirlwind Decade of CRISPR

The New York Times looks back at the 10 years since the University of California, Berkeley's Jennifer Doudna and her colleagues published their CRISPR paper.

PNAS Papers on Blue Cone Monochromacy Structural Variants, HIV-1 Mutant, T-ALL

In PNAS this week: structural variants linked to blue cone monochromacy, HIV-1 variants affecting the matrix protein p17, and more.