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Hey, Phred, Thanks for the Inaccuracies

Following up on her post last week asking about the accuracy of basecallers, Sandra Porter writes that she succeeded in her quest to find someone who had done a thorough study of chromatogram data processed with phred. Applied Biosystems and collaborators at Wash U and Baylor did work on this a few years ago in a review of 20,000 chromatograms. The upshot, in a quote from ABI's results: "Since phred replaces (and ignores) the initial called sequence, re-processing KB-analyzed samples with phred will, on average, degrade the accuracy of the analysis in terms of actual sequence error," according to the post.

 

The Scan

Billions for Antivirals

The US is putting $3.2 billion toward a program to develop antivirals to treat COVID-19 in its early stages, the Wall Street Journal reports.

NFT of the Web

Tim Berners-Lee, who developed the World Wide Web, is auctioning its original source code as a non-fungible token, Reuters reports.

23andMe on the Nasdaq

23andMe's shares rose more than 20 percent following its merger with a special purpose acquisition company, as GenomeWeb has reported.

Science Papers Present GWAS of Brain Structure, System for Controlled Gene Transfer

In Science this week: genome-wide association study ties variants to white matter stricture in the brain, and more.