In the protocols section of Science Signaling, Scott Napper and his colleagues at the University of Saskatchewan report on their development of species-specific peptide arrays for kinome analysis. They say their approach is feasible since phosphorylation sites are often conserved across species and, because of that, peptide arrays can be made for species that do not have phosphorylation databases but do have genomic information available. The authors "anticipate that these arrays will be valuable for investigating the conservation of biological responses across species, validating animal models of disease, and translating research to clinical applications."
Hey, It's the Kinome
Jan 23, 2009