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He's Making a List, Checking it Twice

Speaking to National Cancer Institute leaders as well as both intramural and extramural investigators last Saturday, Harold Varmus began outlining his "provocative questions exercise," in which he aims to address unanswered questions in cancer research, reports Science Insider. According to Science, Varmus wishes to address "why testicular cancer can be cured with conventional chemotherapy and why obese people are more prone to certain cancers such as colon and breast cancer," and would like to "upend the conventional wisdom that it's impossible to find drugs that block so-called transcription factors, which are proteins that control the expression of genes." Science Insider says that one Varmus' list is complete, the NCI chief may "hold a special competition to invite proposals for several questions and fund, say, 15 of the best ideas."

The Scan

UK Pilot Study Suggests Digital Pathway May Expand BRCA Testing in Breast Cancer

A randomized pilot study in the Journal of Medical Genetics points to similar outcomes for breast cancer patients receiving germline BRCA testing through fully digital or partially digital testing pathways.

Survey Sees Genetic Literacy on the Rise, Though Further Education Needed

Survey participants appear to have higher genetic familiarity, knowledge, and skills compared to 2013, though 'room for improvement' remains, an AJHG paper finds.

Study Reveals Molecular, Clinical Features in Colorectal Cancer Cases Involving Multiple Primary Tumors

Researchers compare mismatch repair, microsatellite instability, and tumor mutation burden patterns in synchronous multiple- or single primary colorectal cancers.

FarGen Phase One Sequences Exomes of Nearly 500 From Faroe Islands

The analysis in the European Journal of Human Genetics finds few rare variants and limited geographic structure among Faroese individuals.