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Herbert Hauptman Dies

Herbert Hauptman, who shared the 1985 Nobel Prize in Chemistry, has died, reports The New York Times. He was 94. Hauptman, a mathematician, worked with chemist Jerome Karle, a classmate from City College, to develop equations to interpret X-ray crystallography films, an advance that greatly sped up the work of analyzing molecular structures. "I don't think there's a single pharmaceutical that's been developed in the last 30 years that hasn't been studied using derivations of what Dr. Hauptman and his colleagues won the Nobel Prize for," says Eaton Lattman, chief executive of the Hauptman-Woodward institute, where Hauptman worked.

The Scan

Myotonic Dystrophy Repeat Detected in Family Genome Sequencing Analysis

While sequencing individuals from a multi-generation family, researchers identified a myotonic dystrophy type 2-related short tandem repeat in the European Journal of Human Genetics.

TB Resistance Insights Gleaned From Genome Sequence, Antimicrobial Response Assays

Researchers in PLOS Biology explore M. tuberculosis resistance with a combination of sequencing and assays looking at the minimum inhibitory concentrations of 13 drugs.

Mendelian Disease Genes Prioritized Using Tissue-Specific Expression Clues

Mendelian gene candidates could be flagged for further functional analyses based on tissue-specific transcriptome and proteome profiles, a new Journal of Human Genetics paper says.

Single-Cell Sequencing Points to Embryo Mosaicism

Mosaicism may affect preimplantation genetic tests for aneuploidy, a single-cell sequencing-based analysis of almost three dozen embryos in PLOS Genetics finds.