Scientists publishing in the journal Clinical Cancer Research this week have found a possible role for miR-192 in the p53 tumor suppressor network. By increasing expression of miR-192 in colon cancer cells, they were able to trigger both G1 and G2 cell cycle arrest, but only in cells with wild-type p53. They found that p53 and p21, both tumor suppressor genes, were overexpressed in cells that also overexpressed miR-192. Analysis with chIP also found that p53 interacted with the miR-192 promoter sequence.
Helping p53 Out
Dec 19, 2008