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Help Is Here for Little Orphan Gene Clusters

The cover paper in the latest edition of Chemistry & Biology ($) comes from William Gerwick and his colleagues at the Scripps Institute of Oceanography. In the paper, the authors present a new method for determining the function of so-called "orphan gene clusters," or segments of DNA whose product is a mystery. The new technique, regrettably called the "genomisotopic approach" (now there's a mouthful), brings together isotope labeling with genome sequence analysis to more consistently identify the output of the DNA in question. The team uses mass spec and NMR to visualize the structure of the ensuing product.

The Scan

Fertility Fraud Found

Consumer genetic testing has uncovered cases of fertility fraud that are leading to lawsuits, according to USA Today.

Ties Between Vigorous Exercise, ALS in Genetically At-Risk People

Regular strenuous exercise could contribute to motor neuron disease development among those already at genetic risk, Sky News reports.

Test Warning

The Guardian writes that the US regulators have warned against using a rapid COVID-19 test that is a key part of mass testing in the UK.

Science Papers Examine Feedback Mechanism Affecting Xist, Continuous Health Monitoring for Precision Medicine

In Science this week: analysis of cis confinement of the X-inactive specific transcript, and more.