The cover paper in the latest edition of Chemistry & Biology ($) comes from William Gerwick and his colleagues at the Scripps Institute of Oceanography. In the paper, the authors present a new method for determining the function of so-called "orphan gene clusters," or segments of DNA whose product is a mystery. The new technique, regrettably called the "genomisotopic approach" (now there's a mouthful), brings together isotope labeling with genome sequence analysis to more consistently identify the output of the DNA in question. The team uses mass spec and NMR to visualize the structure of the ensuing product.
Help Is Here for Little Orphan Gene Clusters
Jan 29, 2007