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Help Is Here for Little Orphan Gene Clusters

The cover paper in the latest edition of Chemistry & Biology ($) comes from William Gerwick and his colleagues at the Scripps Institute of Oceanography. In the paper, the authors present a new method for determining the function of so-called "orphan gene clusters," or segments of DNA whose product is a mystery. The new technique, regrettably called the "genomisotopic approach" (now there's a mouthful), brings together isotope labeling with genome sequence analysis to more consistently identify the output of the DNA in question. The team uses mass spec and NMR to visualize the structure of the ensuing product.

The Scan

Alzheimer's Risk Gene Among Women

CNN reports that researchers have found that variants in MGMT contribute to Alzheimer's disease risk among women but not men.

Still Hanging Around

The Guardian writes that persistent pockets of SARS-CoV-2 in the body could contribute to long COVID.

Through a Little Spit

Enteric viruses like norovirus may also be transmitted through saliva, not just the fecal-oral route, according to New Scientist.

Nature Papers Present Method to Detect Full Transcriptome, Viruses Infecting Asgard Archaea, More

In Nature this week: VASA-seq approach to detect full transcriptome, analysis of viruses infecting Asgard archaea, and more.