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Halcyon's Days May Have Ended

The technology blog GigaOm reports that DNA sequencing startup Halcyon Molecular has shut down. According to GigaOm, "sources familiar with the Redwood City, Calif.-based company say that it ran out of money."

As previously reported by Daily Scan's sister publication In Sequence, the company was developing a method for sequencing DNA that relied on stretching out single-stranded DNA molecules on a substrate and reading labeled bases by transmission electron microscopy.

The technology promised reads of at least 150 kilobases and as long as 4 megabases, with the ability to sequence a human genome to more than 99.9999-percent consensus accuracy and completeness in less than 10 minutes, at a cost of less than $100.

The firm was founded in 2003 by brothers Michael and William Andregg and received venture capital funding from the Founders Fund, and, in 2009, it was awarded $1.29 million in funding from the National Human Genome Research Institute. Additionally, in 2009, it received just over $244,000 under the Qualifying Therapeutic Discovery Project Program, created by the US Patient Protection and Affordable Care Act.

The Scan

And a Fourth?

A fourth dose of the Pfizer-BioNTech SARS-CoV-2 vaccine in an Israeli study increased antibody levels but did not prevent Omicron variant infections, according to the Financial Times.

For Better Science Software

A virtual institute funded by former Google CEO Eric Schmidt's philanthropy aims to lure software engineers to academia, Science reports.

Recommendation Explanations

The New York Times writes that the US Centers for Disease Control and Prevention is straining to both make and explain decisions based on limited information.

Genome Research Papers on De Novo Mutation Rates, Polyploid Genotyping, Oncogene Epigenomic Translocation

In Genome Research this week: de novo mutations rates in hemoglobin subunits, analysis of variant calling methods for polyploid plants, and more.