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GWAS on the Hunt in Osteoporosis

Researchers have published a large association study in this week's PLoS ONE to find genes linked to hip bone size, which has been identified as one of the key measurable risk factors for hip fractures in osteoporosis. The first such GWAS to look at bone size, the study scanned 380,000 SNPs in 1,000 men and women and identified PLCL1 (phospholipase c-like 1), which had four SNPs associated with hip bone size. Previous studies showed that the PLCL1 protein inhibits IP3 (inositol 1,4,5-trisphosphate)-mediated calcium signaling, an important pathway regulating mechanical sensing of bone cells.

The Scan

Could Cost Billions

NBC News reports that the new Alzheimer's disease drug from Biogen could cost Medicare in the US billions of dollars.

Not Quite Sent

The Biden Administration likely won't meet its goal of sending 80 million SARS-CoV-2 vaccine doses abroad by the end of the month, according to the Washington Post.

DTC Regulation Proposals

A new report calls on UK policymakers to review direct-to-consumer genetic testing regulations, the Independent reports.

PNAS Papers on Mosquito MicroRNAs, Acute Kidney Injury, Trichothiodystrophy

In PNAS this week: microRNAs involved in Aedes aegypti reproduction, proximal tubule cell response to kidney injury, and more.