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GWAS on the Hunt in Osteoporosis

Researchers have published a large association study in this week's PLoS ONE to find genes linked to hip bone size, which has been identified as one of the key measurable risk factors for hip fractures in osteoporosis. The first such GWAS to look at bone size, the study scanned 380,000 SNPs in 1,000 men and women and identified PLCL1 (phospholipase c-like 1), which had four SNPs associated with hip bone size. Previous studies showed that the PLCL1 protein inhibits IP3 (inositol 1,4,5-trisphosphate)-mediated calcium signaling, an important pathway regulating mechanical sensing of bone cells.

The Scan

Pig Organ Transplants Considered

The Wall Street Journal reports that the US Food and Drug Administration may soon allow clinical trials that involve transplanting pig organs into humans.

'Poo-Bank' Proposal

Harvard Medical School researchers suggest people should bank stool samples when they are young to transplant when they later develop age-related diseases.

Spurred to Develop Again

New Scientist reports that researchers may have uncovered why about 60 percent of in vitro fertilization embryos stop developing.

Science Papers Examine Breast Milk Cell Populations, Cerebral Cortex Cellular Diversity, Micronesia Population History

In Science this week: unique cell populations found within breast milk, 100 transcriptionally distinct cell populations uncovered in the cerebral cortex, and more.