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GWAS: The Glory! The Hype! We've Got It All

Mainstream media has picked up on the trend: genome-wide association studies are hot. The AP news team, best known for 10-line breaking news updates, was so excited it burst out with this feature-length article on why GWAS may be even better than sliced bread. "On a single day in February, for example, three separate research groups reported finding several genetic variants tied to the risk of getting prostate cancer," the article says.

For a less breathless view on the subject, check out this post from Daniel MacArthur at his Genetic Future blog. He lists a number of reasons why scientists should be more cautious with these studies. "Despite the hundreds of millions of dollars spent on genome-wide association studies, most of the genetic variance in risk for most common diseases remains undiscovered," he writes. "Some common diseases with a strong heritable component, such as bipolar disease, have remained almost completely resistant to GWAS."

 

The Scan

Missed Early Cases

A retrospective analysis of blood samples suggests early SARS-CoV-2 infections may have been missed in the US, the New York Times reports.

Limited Journal Editor Diversity

A survey finds low diversity among scientific and medical journal editors, according to The Scientist.

How Much of a Threat?

Science writes that need for a provision aimed at shoring up genomic data security within a new US bill is being questioned.

PNAS Papers on Historic Helicobacter Spread, Brain Development, C. difficile RNAs

In PNAS this week: Helicobacter genetic diversity gives insight into human migrations, gene expression patterns of brain development, and more.