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A GWAS Cheat Sheet

At Genomes Unzipped, Jeff Barrett gives a how-to on determining whether a genome-wide association study is "a landmark finding or a dud." Five factors to take into consideration, he says, are sample size, quality control, confounders, replication, and biology. "The biggest challenge to successfully carrying out a GWAS is getting good, clean genotype data. Pay close attention not only to the standard QC metrics ... but also to whether extra attention was focused on the genotypes of the most associated SNPs," he writes. In general, he adds that "you should be suspicious" if the study contained fewer than 1,000 cases and controls.

The Scan

Long COVID-19 Susceptibility Clues Contained in Blood Plasma Proteome

A longitudinal study in eBioMedicine found weeks-long blood plasma proteome shifts after SARS-CoV-2 infection, along with proteomic signatures that appeared to coincide with long Covid risk.

Tibetan Study Finds Adaptive Variant Influencing Skin Pigmentation

With a combination of phenotyping and genetic data, researchers document at PNAS a Tibetan-enriched enhancer variant influencing melanin synthesis and ultraviolet light response.

Domestication Linked to Nervous System Genes in Inbred Mouse Strains

Researchers highlighted more than 300 positively selected genes in domesticated mice, including genes linked to nervous system function or behavior in Genome Biology.

ALS Genetic Testing May Be Informative Across Age Ranges, Study Finds

Researchers in the journal Brain identified clinically actionable variants in a significant subset of older ALS patients, prompting them to point to the potential benefits of broader test use.