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A GWAS for Aneurysm

A group of researchers reports in the American Journal of Human Genetics on a genome-wide association study of abdominal aortic aneurysm. For the discovery phase, they looked at 1,866 people with abdominal aortic aneurysm and 5,435 controls, and followed up their nine leads in 2,871 additional cases and 32,687 controls and then in an additional 1,491 cases and 11,060 controls. From this they linked a variant in the low-density-lipoprotein receptor-related protein 1 gene with risk of abdominal aortic aneurysm. "This gives us a target to look at to work out what causes these aneurysms to grow. If we can do that, we can hopefully find ways to stop them growing and prevent people from needing operations," lead author Matthew Bown from the University of Leicester tells the Guardian.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.