Toronto's The Star speaks with Shinya Yamanaka who recently received the 2009 Canada Gairdner Award for his work on induced pluripotent stem cells. In it, Yamanaka recounts how surprised they were when their method worked. "We thought it would be much more difficult. But as it turns out, all we need are four factors," he says. Yamanaka will also be collaborating with University of Toronto researchers on iPS work.