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The Good News, and the Bad News

The US Senate is pleased by the creation of the new National Center for Advancing Translational Sciences, but recently "scolded" the National Institutes of Health for its messy creation process, reports ScienceInsider's Jocelyn Kaiser. The Senate expressed its grievance in a note that accompanied the 2012 spending bill recently approved by the Senate Appropriations Committee — the bill cuts NIH's budget by 0.6 percent (to $30.5 billion) next year, Kaiser says. NCATS would receive $582 million, less than the $722 million NIH originally requested for the new center. "NIH had also requested $100 million within NCATS for the Cures Acceleration Network, a new program created by the 2010 health care reform bill. Instead, the Senate panel gave CAN $20 million," Kaiser adds. In the report attached to the bill, the Senate committee said NCATS will change the way NIH does business as it relates to translation, but added that it was disappointed by the way the Obama administration had requested funds for the center. According to the report, "The president's 2012 budget released in February included only a 'vague description' of NCATS and no budget details, which 'caused unnecessary uncertainty' and 'contributed to the impression that it was being rushed,'" Kaiser says.

The Scan

Single-Cell Sequencing Points to Embryo Mosaicism

Mosaicism may affect preimplantation genetic tests for aneuploidy, a single-cell sequencing-based analysis of almost three dozen embryos in PLOS Genetics finds.

Rett Syndrome Mouse Model Study Points to RNA Editing Possibilities

Investigators targeted MECP2 in mutant mouse models of Rett syndrome, showing in PNAS that they could restore its expression and dial down symptoms.

Investigators Find Shared, Distinct Genetic Contributors to Childhood Hodgkin Lymphoma

An association study in JAMA Network Open uncovers risk variants within and beyond the human leukocyte antigen locus.

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.