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A Good Idea, But ...

While scientists like reading open-access journals, the EU-funded Study of Open Access Publishing found that researchers are less likely to submit their papers to those journals, reports ScienceInsider. The study surveyed 50,000 scientists, finding that 89 percent of the respondents supported the idea of open-access journals but that 53 percent had at least one paper in an open-access journal. In addition, the study reported two stumbling blocks to why researchers don't submit their work to open-access journals: author fees and a lack of high-quality open-access journals in their field. "Journal quality and impact factor is most important — not [open access] — when deciding where to submit," says Peter Strickland at the International Union of Crystallography, which is the publisher of the open-access Structure Reports Online as well as subscription journals.

The Scan

Drug Response Variants May Be Distinct in Somatic, Germline Samples

Based on variants from across 21 drug response genes, researchers in The Pharmacogenomics Journal suspect that tumor-only DNA sequences may miss drug response clues found in the germline.

Breast Cancer Risk Gene Candidates Found by Multi-Ancestry Low-Frequency Variant Analysis

Researchers narrowed in on new and known risk gene candidates with variant profiles for almost 83,500 individuals with breast cancer and 59,199 unaffected controls in Genome Medicine.

Health-Related Quality of Life Gets Boost After Microbiome-Based Treatment for Recurrent C. Diff

A secondary analysis of Phase 3 clinical trial data in JAMA Network Open suggests an investigational oral microbiome-based drug may lead to enhanced quality of life measures.

Study Follows Consequences of Early Confirmatory Trials for Accelerated Approval Indications

Time to traditional approval or withdrawal was shorter when confirmatory trials started prior to accelerated approval, though overall regulatory outcomes remained similar, a JAMA study finds.