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Getting Them to Stick

Derek Lowe tosses around some ideas for using small molecules as binding partners for immobilizing proteins to solid supports like beads and chips. Affinity chromatography is one way; surface plasmon resonance, which can tell with great sensitivity if something is sticking close to a solid surface, is another current approach that's making headway. "You want the association between the binding partners to be strong enough to be useful, but (in many cases) not so incredibly strong that it can never be broken up again," Lowe says. He adds: "The big problem that people tend to have with all these ideas -- and I’m one of those people, in the end -- is that it’s hard to see how you can rope small molecules to a solid support without changing their character."

The Scan

Gone, But Now Reconstructed SARS-CoV-2 Genomes

In a preprint, a researcher describes his recovery of viral sequences that had been removed from a common database.

Rare Heart Inflammation Warning

The Food and Drug Administration is adding a warning about links between a rare inflammatory heart condition and two SARS-CoV-2 vaccines, Reuters reports.

Sandwich Sampling

The New York Times sent tuna sandwiches for PCR analysis.

Nature Papers Describe Gut Viruses, New Format for Storing Quantitative Genomic Data, More

In Nature this week: catalog of DNA viruses of the human gut microbiome, new dense depth data dump format to store quantitative genomic data, and more.