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The myriad tools for analyzing sequence data — never mind the sheer amount of data itself — can overwhelm researchers just getting into the field. Over at The Scientist, Jeffrey Perkel presents a guide for those new to the community. First off, researchers need a place to store data and compute power to analyze it, but just how much of each will depend on the project. Many institutions have cluster access for its researchers, but for researchers at those that don't, there are other services to turn to, such as Amazon's Cloud or Penn State's Galaxy, among others. On the analysis end, Perkel says that there are "literally hundreds of bioinformatics tools for next-gen sequencing are available, from polished commercial products to rough-around-the-edges freeware solutions." A table at The Scientist includes a list of tools, from Bowtie to Velvet, that may come in handy.

The Scan

mRNA-Based Vaccine on the Way in China

China may soon have its own mRNA-based vaccine, according to Nature News.

Arranged Killing, Fraud Alleged by Prosecutors

The Wall Street Journal reports that prosecutors allege that the co-founder of a biotech arranged to have a business associate who threatened to expose him as a fraud killed.

Whirlwind Decade of CRISPR

The New York Times looks back at the 10 years since the University of California, Berkeley's Jennifer Doudna and her colleagues published their CRISPR paper.

PNAS Papers on Blue Cone Monochromacy Structural Variants, HIV-1 Mutant, T-ALL

In PNAS this week: structural variants linked to blue cone monochromacy, HIV-1 variants affecting the matrix protein p17, and more.