This week in PLoS Genetics, investigators at Stanford University present "a novel synthetic human reference sequence that is ethnically concordant," which they used to analyze "genomes from a nuclear family with history of familial thrombophilia." With such a reference, the team inferred recombination sites within the pedigree "to the lowest median resolution demonstrated to date — fewer than 1,000 base pairs," used family inheritance statistical analysis "to control sequenc

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Researchers hope to tease out the signature effects that different carcinogens leave on the genome to determine their contributions to disease, Mosaic reports.

The Wall Street Journal looks into the cost of new gene therapies.

An Imperial College London-led team reports that it was able to use a gene drive to control a population of lab mosquitos.

In PNAS this week: genomic effects of silver fox domestication, limited effect of mitochondrial mutations on aging in fruit flies, and more.