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A group of researchers, led by Constantin Polychronakos, identified a type I diabetes gene through a two-stage genome-wide association study. They also report in the advance online section of Nature that they predict the gene product of KIAA0350 to be a lectin and they hypothesize that a change to its binding site on an activating cytotoxic T-cell could result in the autoimmune response seen in type I diabetes.

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