Mind the Gap

A new study in the New England Journal of Medicine shows that there are still places where we could use a little more knowledge, says Yale cardiologist Harlan Krumholz in Forbes. The study compares different ways of using diuretics to treat patients with heart failure, but what it really shows, Krumholz says, is the need for more comparative effectiveness research.

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Microsoft co-founder Paul Allen also contributed to brain research, NPR reports.

The New York Times reports on the shifting interpretations of what some genetic variants mean over time.

MIT's Technology Review reports on Genentech's pursuit of personalized cancer vaccines.

In Cell this week: investigation of metastatic tumor evolution, more than 16,000 genetic variants introduced into the budding yeast model organism, and more.