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Game, Set, Match

The news that federally-funded embryonic stem cell researchers have been waiting for has arrived: They can continue to do their work without fear that their funding will be cut off, says the Associated Press' Nedra Pickler. A lawsuit filed last August, which researchers feared would put their work in jeopardy, has been thrown out of court. The lawsuit, filed by two adult stem cell researchers, alleged that the research on human embryonic stem cells being funded by NIH violated the 1996 Dickey-Wicker law, which prohibits the use of federal dollars on any research that harms or destroys a human embryo, Pickler says. The Obama administration — which garnered the praise of stem cell scientists when it increased the number of stem cell lines that could be used in research done with federal money in 2009 — immediately said it would appeal the ruling. The US Circuit Court of Appeals sided with the administration, overturning the injunction on stem cell research, pending the outcome of the appeal. Lawyers for the researchers who brought the suit say they're weighing their options in the face of dismissal, but researchers are breathing a little easier now. "The scientific community applauded the ruling, as did National Institutes of Health Director Francis Collins," Pickler says. In a statement to the press, Collins says, "This ruling will help ensure this groundbreaking research can continue to move forward."

The Scan

Study Points to Tuberculosis Protection by Gaucher Disease Mutation

A mutation linked to Gaucher disease in the Ashkenazi Jewish population appears to boost Mycobacterium tuberculosis resistance in a zebrafish model of the lysosomal storage condition, a new PNAS study finds.

SpliceVault Portal Provides Look at RNA Splicing Changes Linked to Genetic Variants

The portal, described in Nature Genetics, houses variant-related messenger RNA splicing insights drawn from RNA sequencing data in nearly 335,700 samples — a set known as the 300K-RNA resource.

Automated Sequencing Pipeline Appears to Allow Rapid SARS-CoV-2 Lineage Detection in Nevada Study

Researchers in the Journal of Molecular Diagnostics describe and assess a Clear Labs Dx automated workflow, sequencing, and bioinformatic analysis method for quickly identifying SARS-CoV-2 lineages.

UK Team Presents Genetic, Epigenetic Sequencing Method

Using enzymatic DNA preparation steps, researchers in Nature Biotechnology develop a strategy for sequencing DNA, along with 5-methylcytosine and 5-hydroxymethylcytosine, on existing sequencers.