Skip to main content
Premium Trial:

Request an Annual Quote

Fun with Unix and Sequencing Data

There's an on-going thread at SEQanswers ("Hello - I use to think I was good with a computer") with tips on dealing with sequencing data. First, Jon_Keats posts some gems that he recently learned, namely that "my boss should have made me read and do the 'Unix and Perl for Biologist' tutorial years ago" and "BWA can align on my laptop ... cool ... next-gen/2nd gen alignment on a laptop and I [thought] I needed a super computer." Keats later posts a more technical fast-start guide for using Unix and Xcode as well as compiling applications.

HT: Nils Homer

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.