Derek Lowe is not a fan of impact factors, and suggests that we all start pretending they just don't exist. But, realistically, he writes, a compromise might be more helpful: "Tell junior faculty and staff that their publication records will be a part of their evaluations, of course. But tell them that they're not the most important part, and that a short publication list can be balanced out by other factors," he writes.

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A new Nature Biotechnology paper reports that CRISPR-Cas9 gene editing can lead to large deletions or complex rearrangements that could be pathogenic.

The UK's Nuffield Council on Bioethics says genetically modifying human embryos could be morally permissible, according to the Guardian.

The Wall Street Journal likens a prototype developed by Synthetic Genomics to a "biological fax machine."

In PNAS this week: strategy for reactivating Rett syndrome-linked MECP2, small molecules able to suppress Staphylococcus aureus virulence, and more.