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Frustrating, Yes

Mike the Mad Biologist writes on his blog that there's some not so high-quality genome annotation in GenBank. Annotation, he says, hadn’t been the rate-limiting step until recently in sequencing and now that it is, many labs are turning to automated gene prediction software. However, he adds that software correctly calls about 95 percent of genes and that not all labs have check in place to find bad calls. “This is bad for people who want to pull these genomes out of GenBank and study them,” Mike writes. “But this also screws up gene identification of new genomes. High quality gene prediction processes rely on both ab initio rules and previously identified genes from other genomes.”

The Scan

Another Resignation

According to the Wall Street Journal, a third advisory panel member has resigned following the US Food and Drug Administration's approval of an Alzheimer's disease drug.

Novavax Finds Its Vaccine Effective

Reuters reports Novavax's SARS-CoV-2 vaccine is more than 90 percent effective in preventing COVID-19.

Can't Be Used

The US Food and Drug Administration says millions of vaccine doses made at an embattled manufacturing facility cannot be used, the New York Times reports.

PLOS Papers on Frozen Shoulder GWAS, Epstein-Barr Effects on Immune Cell Epigenetics, More

In PLOS this week: genome-wide association study of frozen shoulder, epigenetic patterns of Epstein-Barr-infected B lymphocyte cells, and more.