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Frustrating, Yes

Mike the Mad Biologist writes on his blog that there's some not so high-quality genome annotation in GenBank. Annotation, he says, hadn’t been the rate-limiting step until recently in sequencing and now that it is, many labs are turning to automated gene prediction software. However, he adds that software correctly calls about 95 percent of genes and that not all labs have check in place to find bad calls. “This is bad for people who want to pull these genomes out of GenBank and study them,” Mike writes. “But this also screws up gene identification of new genomes. High quality gene prediction processes rely on both ab initio rules and previously identified genes from other genomes.”

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.