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Free Bioinformatics Tools

Bitesize Bio has compiled a handy list of free online molecular biology and bioinformatics databases and tools. Among the best are the Online Bioinformatics Resource Collection, which provides links and annotations for more than 2,000 bioinformatics databases and software tools; the BioMed Central databases; the Online Resource Finder for Lifesciences, which provides searches for online resources introduced in peer-reviewed papers in the life sciences; and the Nucleic Acids Research Bioinformatics Links Directory.

The Scan

Myotonic Dystrophy Repeat Detected in Family Genome Sequencing Analysis

While sequencing individuals from a multi-generation family, researchers identified a myotonic dystrophy type 2-related short tandem repeat in the European Journal of Human Genetics.

TB Resistance Insights Gleaned From Genome Sequence, Antimicrobial Response Assays

Researchers in PLOS Biology explore M. tuberculosis resistance with a combination of sequencing and assays looking at the minimum inhibitory concentrations of 13 drugs.

Mendelian Disease Genes Prioritized Using Tissue-Specific Expression Clues

Mendelian gene candidates could be flagged for further functional analyses based on tissue-specific transcriptome and proteome profiles, a new Journal of Human Genetics paper says.

Single-Cell Sequencing Points to Embryo Mosaicism

Mosaicism may affect preimplantation genetic tests for aneuploidy, a single-cell sequencing-based analysis of almost three dozen embryos in PLOS Genetics finds.