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Fred and Ginger Never Had This Problem

Nearly every eukaryote has at least two separate genomes — one in the central nucleus and one in the mitochondria — and when those two genomes act like a pair of "mismatched" partners, the "dance" they do falls apart and the results can be "disastrous," Not Exactly Rocket Science's Ed Yong says. The mitochondrial genome and the nuclear genome, though they evolved in different ways, must work together within the cell. Yong says that according to a paper recently published in BioEssays, "some of the most fundamental aspects of eukaryotic life are driven by the need to keep these two genomes dancing in time," and that many species evolve the way they do because of this pressure to make this "mitonuclear" match.

The Scan

Researchers Compare WGS, Exome Sequencing-Based Mendelian Disease Diagnosis

Investigators find a diagnostic edge for whole-genome sequencing, while highlighting the cost advantages and improving diagnostic rate of exome sequencing in EJHG.

Researchers Retrace Key Mutations in Reassorted H1N1 Swine Flu Virus With Avian-Like Features

Mutations in the acidic polymerase-coding gene boost the pathogenicity and transmissibility of Eurasian avian-like H1N1 swine influenza viruses, a PNAS paper finds.

Genome Sequences Reveal Evolutionary History of South America's Canids

An analysis in PNAS of South American canid species' genomes offers a look at their evolutionary history, as well as their relationships and adaptations.

Lung Cancer Response to Checkpoint Inhibitors Reflected in Circulating Tumor DNA

In non-small cell lung cancer patients, researchers find in JCO Precision Oncology that survival benefits after immune checkpoint blockade coincide with a dip in ctDNA levels.