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On Fraud

The Wall Street Journal's Health Blog speaks with John Dahlberg, who is the director of the Division of Investigative Oversight in the Office of Research Integrity at HHS, about scientific fraud. Dahlberg says that fraud cases are rare and when they do occur it's often a grad student or a postdoc succumbing to pressure, either from a PI or self-imposed. If the damage is serious, Dahlberg says "we'll recommend voluntary exclusion. It's like a disbarment. They will not seek [federal] funds or spend them, including Medicare and Medicaid."

The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.