The Four Types

The Cancer Genome Atlas reports on four breast cancer subtypes, in Nature. The researchers examined tumor and germline DNA from 825 patients using a number of different approaches, including mRNA expression microarrays DNA methylation chips, and whole-exome sequencing, among others. From this profiling, the researchers found that mutations in only three genes, TP53, PIK3CA, and GATA3, occurred in more than 10 percent of breast tumors.

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