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Following the Crowd (Science)

The Chronicle of Higher Education's Jeffery Young says crowd science is taking hold in several scientific disciplines as researchers pool their resources and collaborate to make sense of their data and discoveries. When it comes to bioscience, Young says, researchers are finding that decoding entire genomes means a shift in the culture that previously dictated that data was never to be shared. For example, researchers are now using wikis to create "a genetic road map," like GenMAPP, Young says. Researchers hesitated to participate, at first, because they had no incentive to add their data to the pile. But in 2007, the GenMAPP developers added certain features allowing researcher to keep data private until it was published in a journal, and made adding data to the wiki easier and less time consuming, Young adds, which pushed participation rates up. "More researchers — and even some pharmaceutical companies — are realizing that genetic information is truly useful only when aggregated," Young says.

The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.