First Things First

Clinical genome sequencing should start as way to diagnose patients, rather than as a broad screening tool, says a group of UK researchers in the British Medical Journal.

The UK's National Health Service is taking on a project to sequence some 100,000 patients' genomes, which the researchers led by Caroline Wright at the Wellcome Trust Sanger Institute say underlines the need for a "clear testing policy."

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An opinion piece in the Guardian argues that President Donald Trump is uninterested in science and that might not be a bad thing for the field.

The San Francisco Chronicle reports the Veterans Affairs Health System is studying whether genetic testing can help prescribe better depression therapies.

Stat News reports that Spark Therapeutics' Luxturna is now being used to treat a wider array of patients.

In Genome Biology this week: transcription factor use among brittle stars, single-cell RNA sequencing strategy, and more.