First Things First

Clinical genome sequencing should start as way to diagnose patients, rather than as a broad screening tool, says a group of UK researchers in the British Medical Journal.

The UK's National Health Service is taking on a project to sequence some 100,000 patients' genomes, which the researchers led by Caroline Wright at the Wellcome Trust Sanger Institute say underlines the need for a "clear testing policy."

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Differences in DNA methylation could be used to distinguish between DNA samples obtained from identical twins, researchers say.

A retrovirus that's been integrated into the human genome appears to have a role in embryonic development, researchers report.

A report from MIT identifies areas of scientific research where declining research support is hindering needed advances.

In PLOS this week: phylogenetic study of hepatitis E viruses in Swedish moose, recombination sites in the honeybee genome, and more.