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First Step: Your Netbook Won't Cut It

Bioinformatics Zen's Michael Barton has a post on performing analysis of massive data sets -- "gigabytes of data with millions of data points" and his experience as a biologist in handling this. He says his preference is "to use a database to store and format data as I think this make projects easier to maintain compared with using just scripts." He also lists several common steps for tackling a project of this scale, including adding database indices, using a fast language interpreter, and deleting unnecessary data and analysis (among many others).

The Scan

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.

Study Reveals Potential Sex-Specific Role for Noncoding RNA in Depression

A long, noncoding RNA called FEDORA appears to be a sex-specific regulator of major depressive disorder, affecting more women, researchers report in Science Advances.

New mRNA Vaccines Offer Hope for Fighting Malaria

A George Washington University-led team has developed mRNA vaccines for malaria that appear to provide protection in mice, as they report in NPJ Vaccines.

Unique Germline Variants Found Among Black Prostate Cancer Patients

Through an exome sequencing study appearing in JCO Precision Oncology, researchers have found unique pathogenic or likely pathogenic variants within a cohort of Black prostate cancer patients.