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First the Nobel, Next the NYT Interview

Carol Greider, Johns Hopkins researcher and a winner of the Nobel prize last week for her work on telomeres, submits to a Q&A with the New York Times. Asked about the timing of this prize -- Greider has for years been shortlisted as a potential laureate -- she responded, "I think it’s clear now that the basic science we did is important to understanding cancers, some human genetic diseases and the age associated degenerative diseases. The clinical relevance still needs to be understood in the medical community."

The Scan

Study Finds Sorghum Genetic Loci Influencing Composition, Function of Human Gut Microbes

Focusing on microbes found in the human gut microbiome, researchers in Nature Communications identified 10 sorghum loci that appear to influence the microbial taxa or microbial metabolite features.

Treatment Costs May Not Coincide With R&D Investment, Study Suggests

Researchers in JAMA Network Open did not find an association between ultimate treatment costs and investments in a drug when they analyzed available data on 60 approved drugs.

Sleep-Related Variants Show Low Penetrance in Large Population Analysis

A limited number of variants had documented sleep effects in an investigation in PLOS Genetics of 10 genes with reported sleep ties in nearly 192,000 participants in four population studies.

Researchers Develop Polygenic Risk Scores for Dozens of Disease-Related Exposures

With genetic data from two large population cohorts and summary statistics from prior genome-wide association studies, researchers came up with 27 exposure polygenic risk scores in the American Journal of Human Genetics.